PCI 34051

PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 µM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 µM, respectively). PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 µM), but not in other hematopoietic or solid tumor lines. This compound has also been used to support a critical role for HDAC8 in the coordinated deacetylation of the core cohesion component SMC3 during mitosis.Formal Name: N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide. CAS Number: 950762-95-5. Molecular Formula: C17H16N2O3. Formula Weight: 296.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 230, 285 nm. SMILES: ONC(C1=CC2=C(C=CN2CC3=CC=C(OC)C=C3)C=C1)=O. InChi Code: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20). InChi Key: AJRGHIGYPXNABY-UHFFFAOYSA-N.