Paromomycin (sulfate)

Paromomycin is an aminoglycoside antibiotic that is effective against Gram-negative and Gram-positive bacteria (MICs = 0.08-3.9 µg/ml). It also has antiprotozoal properties and decreases the parasite burden of mice infected with the leishmanial strain L. tropica when administered at doses of 50 mg/kg and 15 mg/kg, through intramuscular or intralesional routes, respectively. Paromomycin binds to the tRNA decoding A site of the 16S ribosomal RNA in bacteria, inducing a conformational change that disrupts translation and inhibits protein synthesis.Formal Name: O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-O-beta-D-ribofuranosyl-(1->5)-O-[2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy-D-streptamine, sulfate. CAS Number: 1263-89-4. Molecular Formula: C23H45N5O14 . XH2SO4. Formula Weight: 615.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC[C@H]1O[C@H](O[C@@]2([H])[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@H]3O)[C@@H](O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O.O=S(O)(O)=O. InChi Code: InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22,1-5(2,3)4/h5-23,29-36H,1-4,24-28H2,(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,/m1./s1. InChi Key: LJRDOKAZOAKLDU-UDXJMMFXSA-N.