Parishin A

Parishin A is a phenolic glycoside originally isolated from G. elata that has lifespan extending and antioxidant activities. It increases the replicative lifespan of S. cerevisiae when used at concentrations ranging from 3 to 30 µM. Parishin A (3-30 µM) also increases superoxide dismutase (SOD) activity, decreases malondialdehyde (MDA) levels, and inhibits hydrogen peroxide-induced cell death in yeast. In vivo, parishin A is metabolized to gastrodin, p-hydroxybenzyl alcohol, parishin B, and parishin C (Cay-25127).Formal Name: [3-[[[4-(beta-D-glucopyranosyloxy)phenyl]methoxy]carbonyl]-3-hydroxy-1,5-dioxo-1,5-pentanediyl]bis(oxymethylene-4,1-phenylene) bis-beta-D-glucopyranoside. CAS Number: 62499-28-9. Molecular Formula: C45H56O25. Formula Weight: 996.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 223 nm. SMILES: OC[C@H]1O[C@@H](OC2=CC=C(COC(CC(O)(C(OCC3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)=O)CC(OCC5=CC=C(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C=C5)=O)=O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C45H56O25/c46-15-27-32(51)35(54)38(57)41(68-27)65-24-7-1-21(2-8-24)18-62-30(49)13-45(61,44(60)64-20-23-5-11-26(12-6-23)67-43-40(59)37(56)34(53)29(17-48)70-43)14-31(50)63-19-22-3-9-25(10-4-22)66-42-39(58)36(55)33(52)28(16-47)69-42/h1-12,27-29,32-43,46-48,51-59,61H,13-20H2/t27-,28-,29-,32-,33-,34-,35+,36+,37+,38-,39-,40-,41-,42-,43-/m1/s1. InChi Key: WYKQPGOKTKQHQG-SHGJSZTHSA-N. Origin: Plant/Gastrodia elata.