Paraxanthine

Paraxanthine is an active metabolite of caffeine (Cay-14118). It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively). In vivo, paraxanthine (30 mg/kg) increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA (N6-cyclopentyladenosine, Cay-21448) or the adenosine A2 receptor agonist CGS 21680 (Cay-17126) in rats not habituated to caffeine. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.Formal Name: 3,7-dihydro-1,7-dimethyl-1H-purine-2,6-dione. CAS Number: 611-59-6. Synonyms: 1,7-Dimethylxanthine, NSC 400018. Molecular Formula: C7H8N4O2. Formula Weight: 180.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 269 nm. SMILES: O=C(C(N(C)C=N1)=C1N2)N(C)C2=O. InChi Code: InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13). InChi Key: QUNWUDVFRNGTCO-UHFFFAOYSA-N.