Paraherquamide A

Description: Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 µg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg). Target: Others. Smiles: CN1[C@]23[C@](C(C)(C)[C@]4(C2)C=5C(NC4=O)=C6C(=CC5)OC(C)(C)C=CO6)(C[C@]7(N(C3)CC[C@@]7(C)O)C1=O)[H]