Palonosetron N-oxide

Description: Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. Target: Others. Smiles: [H][C@@]12CCCc3cccc(C(=O)N(C1)[C@@H]1CN4(=O)CCC1CC4)c23 , THB:12:14:19.18:22.21, . References: Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004)