P32/98 hemifumarate

Description: P32/98 hemifumarate is a dipeptidyl peptidase IV (DPP4) inhibitor with hypoglycemic properties that improves insulin sensitivity and beta-cell responsiveness in the Zucker diabetic rat model, and may be useful in studies of type 2 diabetes and colitis. Target: DPP-4. Smiles: OC(/C=C/C(O)=O)=O.CC[C@H](C)[C@H](N)C(N1CCSC1)=O.CC[C@H](C)[C@H](N)C(N2CCSC2)=O. References: Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008,10(10):850-861.