P-gp inhibitor 5

Description: P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor, reducing P-gp activity by a factor of 2.5 and 3.0 at 1.25 µM and 2.5 µM, respectively. It exhibits anti-proliferative effects on certain cancer cells and restores cellular sensitivity to Vincristine and Paclitaxel, reversing the multidrug resistant (MDR) phenotype of ABCB1/Flp-InTM-293 and KBvin. Target: Others. Smiles: O(C(C)=O)C1=C2C(=C(NC(=O)C3=C(Cl)C=CC=C3)OC2=CC(=C1)C4=CC=C(OC)C=C4)C5=CC=CS5