Oxyphenonium (bromide)

Oxyphenonium is an antagonist of muscarinic acetylcholine receptors that binds to muscarinic receptors on isolated guinea pig atria and ileum (Kds = 0.11 and 0.17 nM, respectively). In vivo, oxyphenonium reverses carbaminocholine- and acetylcholine-induced decreases in blood pressure in anesthetized cats (ED50s = 0.591 and 1 µg/kg, respectively). It decreases rumenal ulcer formation in rats and suppresses insulin-induced gastric secretion in dogs with gastric fistulas. Oxyphenonium also prevents form-deprivation myopia (FDM) in a chick model of experimental myopia. Formulations containing oxyphenonium have been used to treat peptic ulcers.Formal Name: 2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]-N,N-diethyl-N-methyl-ethanaminium, monobromide. CAS Number: 50-10-2. Synonyms: (±)-Oxyphenonium. Molecular Formula: C21H34NO3 . Br. Formula Weight: 428.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 25 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CC[N+](CCOC(C(C1=CC=CC=C1)(O)C2CCCCC2)=O)(C)CC.[Br-]. InChi Code: InChI=1S/C21H34NO3.BrH/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19,/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3,1H/q+1,/p-1. InChi Key: UKLQXHUGTKWPSR-UHFFFAOYSA-M.