OXSI-2

Description: OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets. Target: Syk. Smiles: C(=C1C=2C(NC1=O)=CC=C(S(N)(=O)=O)C2)C=3C=4C(N(C)C3)=CC=CC4. References: Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 9,18(6). pii: E1238. doi: 10.3390/ijms18061238. PubMed PMID: 28598382, PubMed Central PMCID: PMC5486061.