Oxotremorine (sesquifumarate)

Oxotremorine is an agonist of muscarinic acetylcholine receptors (mAChRs). It binds to M1, M2, M3, and M4 mAChRs (Kis = 3.31, 9.33, 5.24, and 7.08 µM, respectively, for the human receptors). It inhibits acetylcholine (ACh, Cay-23829) release in rat cerebral cortical slices when used at a concentration of 10 µM, an effect that can be reversed by the non-selective mAChR antagonist atropine (Cay-12008). Oxotremorine induces tremors, salivation, and lacrimation in mice (ED50s = 0.11, 0.22, and 0.28 mg/kg). It induces analgesia in the hot plate test in mice when administered at a dose of 0.5 mg/kg. Oxotremorine has been used to induce parkinsonian symptoms as a model of Parkinson's disease in mice.Formal Name: 1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-2-pyrrolidinone, 2E-butenedioate (2:3). CAS Number: 17360-35-9. Molecular Formula: C12H18N2O . 3/2C4H4O4. Formula Weight: 380.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: O=C1N(CC#CCN2CCCC2)CCC1.O=C3N(CC#CCN4CCCC4)CCC3.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O. InChi Code: InChI=1S/2C12H18N2O.3C4H4O4/c2*15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13,3*5-3(6)1-2-4(7)8/h2*1-2,5-11H2,3*1-2H,(H,5,6)(H,7,8)/b,,3*2-1+. InChi Key: WLYYOFJEBGHKEC-VQYXCCSOSA-N.