OSI-027

Description: OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kalpha, PI3Kbeta, PI3Kgamma or DNA-PK. Phase 1. Target: Autophagy, PI3K, mTOR, DNA-PK. Smiles: COc1cccc2=C\C(N=c12)=c1/nc(C2CCC(CC2)C(O)=O)n2NC=NC(N)=c12. References: Falcon BL, et al. Cancer Res, 2011, 71(5), 1573-1583.