Oosporein

Oosporein is a mycotoxin that has been found in Beauveria and has diverse biological activities. It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 µM, respectively. Oosporin induces lethality in day-old cockerels (LD50 = 6.12 mg/kg). It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 µg/ml. Oosporein inhibits herpes simplex 1 (HSV-1), but not HeLa cell or E. coli, DNA polymerase (IC50s = 75, 610, and >700 µM, respectively). It is active against the bacterium S. pneumoniae (MIC = 32 µg/ml) and the plant pathogenic fungus P. infestans (MIC = 16 µM).Formal Name: 2,2',5,5'-tetrahydroxy-4,4'-dimethyl-[bi-1,4-cyclohexadien-1-yl]-3,3',6,6'-tetrone. CAS Number: 475-54-7. Synonyms: NSC 88466. Molecular Formula: C14H10O8. Formula Weight: 306.2. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CC1=C(O)C(C(C2=C(O)C(C(C)=C(O)C2=O)=O)=C(O)C1=O)=O. InChi Code: InChI=1S/C14H10O8/c1-3-7(15)11(19)5(12(20)8(3)16)6-13(21)9(17)4(2)10(18)14(6)22/h15,17,20,22H,1-2H3. InChi Key: DHMPJEGFPQTNFX-UHFFFAOYSA-N.