ONO-7300243

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, IC50 = 0.16 µM). It is selective for LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively). ONO-7300243 dose-dependently reduces intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg) without affecting mean blood pressure.Formal Name: 4-[[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl]-benzeneacetic acid. CAS Number: 638132-34-0. Molecular Formula: C28H31NO5. Formula Weight: 461.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml. SMILES: OC(CC1=CC=C(CN(CCCC2=CC=CC=C2)C(C3=CC(OC)=C(C)C(OC)=C3)=O)C=C1)=O. InChi Code: InChI=1S/C28H31NO5/c1-20-25(33-2)17-24(18-26(20)34-3)28(32)29(15-7-10-21-8-5-4-6-9-21)19-23-13-11-22(12-14-23)16-27(30)31/h4-6,8-9,11-14,17-18H,7,10,15-16,19H2,1-3H3,(H,30,31). InChi Key: WGABOZPQOOZAOI-UHFFFAOYSA-N.