ONO-4817

ONO-4817 is an inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 0.5 and 0.8 nM, respectively, for the human enzymes). It is selective for MMP-2 and -9 over MMP-3 and -1 (IC50s = 26 and 2,500 nM, respectively). ONO-4817 (5 µg/ml) decreases bronchoalveolar lavage fluid (BALF) neutrophil infiltration in an ex vivo rat model of pulmonary ischemia-reperfusion injury. It inhibits intra-artricular LPS-induced release of proteoglycans in knee joints in a guinea pig model of arthritis when administered at doses of 30 and 100 mg/kg. ONO-4817 (1% in the diet) reduces the number of lung metastases in a PC14PE6 lung cancer mouse xenograft model.Formal Name: N-[(1S,3S)-1-[(ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxy-benzamide. CAS Number: 223472-31-9. Synonyms: MMP Inhibitor V. Molecular Formula: C22H28N2O6. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: ONC([C@@H](C)C[C@@H](COCOCC)NC(C(C=C1)=CC=C1OC2=CC=CC=C2)=O)=O. InChi Code: InChI=1S/C22H28N2O6/c1-3-28-15-29-14-18(13-16(2)21(25)24-27)23-22(26)17-9-11-20(12-10-17)30-19-7-5-4-6-8-19/h4-12,16,18,27H,3,13-15H2,1-2H3,(H,23,26)(H,24,25)/t16-,18-/m0/s1. InChi Key: HDWWQELUBWGQGA-WMZOPIPTSA-N.