Olmesartan

Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil (Cay-11614). It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma. Olmesartan is selective for AT1 over AT2 (IC50 = >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II (Cay-17150, pD2 = 9.9) but not phenylephrine (Cay-17205, Cay-18619) or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats.Formal Name: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid. CAS Number: 144689-24-7. Synonyms: CS 088, RNH 6270. Molecular Formula: C24H26N6O3. Formula Weight: 446.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.2 mg/ml. SMILES: OC(C)(C)C1=C(C(O)=O)N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(CCC)=N1. InChi Code: InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29). InChi Key: VTRAEEWXHOVJFV-UHFFFAOYSA-N.