Ochratoxin A

Ochratoxin A (OTA) is a mycotoxin that has been found in Penicillium and is an active metabolite of OTC (Cay-20183). It is formed from OTC in vivo, however, OTC can also be formed from OTA by gut microbiota. OTA (120 µg/kg) increases renal lipid peroxide levels and the number of apoptotic cells, as well as reduces renal superoxide dismutase (SOD) activity in rats. Topical application of OTA (80 µg/animal) induces DNA damage, cell cycle arrest at the G0/G1 phase, and apoptosis in mouse skin cells. It also initiates tumor formation in a two-stage mouse skin tumorigenesis model. OTA has been found in food products and poultry feed.Formal Name: N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine. CAS Number: 303-47-9. Synonyms: NSC 201422, NSC 221991, OTA. Molecular Formula: C20H18ClNO6. Formula Weight: 403.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 213, 331 nm. SMILES: O=C(O)C(NC(C1=CC(Cl)=C(C[C@@H](C)OC2=O)C2=C1O)=O)CC3=CC=CC=C3. InChi Code: InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1. InChi Key: RWQKHEORZBHNRI-BMIGLBTASA-N.