Obafluorin

Description: Obafluorin is a beta-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 µg/ml for all). Target: Others. Smiles: Oc1cccc(C(=O)N[C@H]2[C@@H](Cc3ccc(cc3)N(=O)=O)OC2=O)c1O. References: Pu, Y., Lowe, C., Sailer, M., et al. Synthesis, stability, and antimicrobial activity of (+)-obafluorin and related beta-lactone antibiotics. J. Org. Chem. 59(13), 3642-3655 (1994).