OBA-09

OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties. It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1beta, inducible nitric oxide synthase (iNOS), COX-2, and TNF-alpha in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO). It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.Formal Name: 2-(1,2-dioxopropoxy)-benzoic acid. CAS Number: 856095-68-6. Molecular Formula: C10H8O5. Formula Weight: 208.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMSO: 40mg/mL, Ethanol: 80mg/mL, PBS (pH 7.2): 2.7mg/mL. lambdamax: 238, 300 nm. SMILES: O=C(O)C1=C(OC(C(C)=O)=O)C=CC=C1. InChi Code: InChI=1S/C10H8O5/c1-6(11)10(14)15-8-5-3-2-4-7(8)9(12)13/h2-5H,1H3,(H,12,13). InChi Key: ULWCDKMLERRCJA-UHFFFAOYSA-N.