NVP-DKY709

NVP-DKY709 is a degrader of Ikaros family zinc finger protein 2 (IKZF2) with a half-maximal degradation concentration (DC50) value of 4 nM. It is selective for IKZF2 over 8,656 other proteins, including IKZF1, IKZF3, and IKZF5, at 2.5 µM, but it does degrade IKZF4, which has the same zinc finger 2 beta-hairpin sequence as IKZF2, and Sal-like protein 4 (SALL4, DC50s = 13 and 2 nM, respectively). It increases IL-2 secretion induced by phytohemagglutinin in Jurkat T cells in a concentration-dependent manner. NVP-DKY709 (100 mg/kg), alone or in combination with an antibody against programmed death protein 1 (PD-1), decreases tumor volume in an MDA-MB-231 humanized mouse xenograft model.Formal Name: 3-[1,3-dihydro-1-oxo-5-[1-(phenylmethyl)-4-piperidinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. CAS Number: 2291360-73-9. Molecular Formula: C25H27N3O3. Formula Weight: 417.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml. SMILES: O=C1C2=CC=C(C3CCN(CC3)CC4=CC=CC=C4)C=C2CN1C5C(NC(CC5)=O)=O. InChi Code: InChI=1S/C25H27N3O3/c29-23-9-8-22(24(30)26-23)28-16-20-14-19(6-7-21(20)25(28)31)18-10-12-27(13-11-18)15-17-4-2-1-3-5-17/h1-7,14,18,22H,8-13,15-16H2,(H,26,29,30). InChi Key: OMISHRJQMYQPMG-UHFFFAOYSA-N.