NVP-BVU972

NVP-BVU972 is an inhibitor of Met kinase (IC50 = 14 nM). It is selective for Met over a panel of 62 additional kinases (IC50s = >1 µM for all). It inhibits proliferation of Met-amplified GTL-16 gastric, MKN45 gastric, and EBC-1 lung cancer cells (IC50s = 66, 32, and 82 nM, respectively). NVP-BVU972 inhibits Met autophosphorylation in GTL-16 cells and Met phosphorylation induced by hepatocyte growth factor (HGF) in A549 cells (IC50s = 7.3 and 22 nM, respectively).Formal Name: 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-quinoline. CAS Number: 1185763-69-2. Molecular Formula: C20H16N6. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 231, 254 nm. SMILES: CN(N=C1)C=C1C2=NN3C(C=C2)=NC=C3CC4=CC(C=CC=N5)=C5C=C4. InChi Code: InChI=1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3. InChi Key: RNCNPRCUHHDYPC-UHFFFAOYSA-N.