NUCC-390 (hydrochloride)

NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist. It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 (plerixafor, Cay-10011332). NUCC-390 (0.0625, 0.125, and 0.25 µM) increases axon length in cultured rat spinal cord motor neurons. In vivo, NUCC-390 (26 mg/kg per day) restores gastrocnemius muscle compound muscle action potentials (CMAPs) in a mouse model of sciatic nerve crush injury. It also restores CMAPs in a mouse model of neuroparalysis induced by Papuan taipan (O. scutellatus) venom.Formal Name: 1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-methanone, dihydrochloride. CAS Number: 2749281-71-6. Molecular Formula: C23H33N5O . 2HCl. Formula Weight: 468.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CCCN1N=C(C(N2CCCCC2)=O)C3=C1CCC(C3)NCCC4=CC=NC=C4.Cl.Cl. InChi Code: InChI=1S/C23H33N5O.2ClH/c1-2-14-28-21-7-6-19(25-13-10-18-8-11-24-12-9-18)17-20(21)22(26-28)23(29)27-15-4-3-5-16-27,,/h8-9,11-12,19,25H,2-7,10,13-17H2,1H3,2*1H. InChi Key: RSYDQYPPGGIWOJ-UHFFFAOYSA-N.