NU 2058

NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 µM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.Formal Name: 6-(cyclohexylmethoxy)-9H-purin-2-amine. CAS Number: 161058-83-9. Synonyms: O6-(Cyclohexylmethyl)guanine. Molecular Formula: C12H17N5O. Formula Weight: 247.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml, Ethanol: 1 mg/ml. lambdamax: 241, 282 nm. SMILES: NC1=NC2=NC=NC2=C(N1)OCC3CCCCC3. InChi Code: InChI=1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17). InChi Key: MWGXGTJJAOZBNW-UHFFFAOYSA-N.