NSC 146109 (hydrochloride)

NSC 146109 is an activator of the tumor suppressor p53 that increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells. It is selective for p53, having no effect on p73 expression in HCT116 cells at a concentration of 2 µM. NSC 146109 activates p53, which induces cell accumulation in the sub-G0/G1 phase and apoptosis in MCF-7 breast cancer cells. It increases p53 expression, decreases expression of the p53 suppressor MDMX, and reduces viability in a panel of breast cancer cell lines when used at a concentration of 0.5 µM. NSC 146109 also reduces growth of AMC-HN9 head and neck carcinoma (HNC) cells in vitro and in vivo when administered alone or in combination with cisplatin (Cay-13119) in a mouse xenograft model at a dose of 70 mg/kg.Formal Name: carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride. CAS Number: 59474-01-0. Synonyms: XI-011. Molecular Formula: C17H16N2S . HCl. Formula Weight: 316.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml, Ethanol: 3 mg/ml. lambdamax: 260 nm. SMILES: NC(SCC1=C2C(C=CC=C2)=C(C)C3=CC=CC=C31)=N.Cl. InChi Code: InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15,/h2-9H,10H2,1H3,(H3,18,19),1H. InChi Key: VIBMUYOXJUCEMA-UHFFFAOYSA-N.