NS 398

NS 398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 µM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 µM, respectively.Formal Name: N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide. CAS Number: 123653-11-2. Molecular Formula: C13H18N2O5S. Formula Weight: 314.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Corn oil: 1 mg/ml (forms a colloidal sus, DMF: 30 mg/ml, DMSO: 25 mg/ml, DMSO-PBS (1:3): 400 µg/ml, Ethanol: 500 µg/ml, Ethanol-PBS (1:1): 4 mg/ml. lambdamax: 214, 238, 296, 337 nm. SMILES: O=S(NC1=C(OC2CCCCC2)C=C([N+]([O-])=O)C=C1)(C)=O. InChi Code: InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3. InChi Key: KTDZCOWXCWUPEO-UHFFFAOYSA-N.