NS 1643

NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 µM). It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1. NS 1643 is commonly used in cells or isolated tissues.Formal Name: N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-urea. CAS Number: 448895-37-2. Molecular Formula: C15H10F6N2O3. Formula Weight: 380.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 211, 240, 261, 292 nm. SMILES: OC1=C(C=C(C=C1)C(F)(F)F)NC(NC2=CC(C(F)(F)F)=CC=C2O)=O. InChi Code: InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26). InChi Key: NJFVQMRYJZHGME-UHFFFAOYSA-N.