Nortriptyline (hydrochloride)

Nortriptyline is a tricyclic antidepressant that blocks norepinephrine and serotonin (Cay-14332) transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM). It also antagonizes serotonin, histamine, muscarinic, and alpha-adrenergic receptors (Kis = 5.0, 8.5, 10, 40, and 60 nM for 5-HT2A, 5-HT2C, H1, alpha1, and M1 receptors, respectively).Formal Name: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, monohydrochloride. CAS Number: 894-71-3. Molecular Formula: C19H21N . HCl. Formula Weight: 299.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 240 nm. SMILES: CNCC/C=C1C2=C(C=CC=C2)CCC3=C/1C=CC=C3.Cl. InChi Code: InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19,/h2-5,7-11,20H,6,12-14H2,1H3,1H. InChi Key: SHAYBENGXDALFF-UHFFFAOYSA-N.