Nornidulin

Description: Nornidulin is a depsidone originally isolated from [A. nidulans] with antibacterial activity against [M. tuberculosis] and [M. ranoe], and antifungal activity against [T. tonsurans] and [M. audouini]. It inhibits the growth of methicillin-resistant [S. aureus] (MRSA, MIC = 2 µg/ml) and has larvicidal activity toward Artemia (LC50 = 1.7 µg/ml). Nornidulin exhibits cytotoxic activity in MOLT-3 cells (IC50 = 35.7 µM) but not in HuCCA-1, HepG2, or A549 cells (IC50s = >116.4 µM). Target: Others. Smiles: C\C=C(/C)c1c(Cl)c(O)c(C)c2OC(=O)c3c(C)c(Cl)c(O)c(Cl)c3Oc12