Norhyodeoxycholic Acid

Description: Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3beta-sulfooxy-7beta-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of delta5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.3. Target: Others. Smiles: [H][C@@]1(CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC(O)=O. References: Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5beta-cholan-23-oic acid derivatives: A convenient and efficient one-carbon degradation of the side chain of natural bile acids. J. Lipid Res. 29(10), 1387-1395 (1988).