Norfluoxetine-d5 (hydrochloride)

Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine (Cay-15900) by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.Formal Name: gamma-[4-(trifluoromethyl)phenoxy]-benzenepropan-1,1,2,2,3-d5-amine, monohydrochloride. CAS Number: 1185132-92-6. Synonyms: Desmethylfluoxetine-d5. Molecular Formula: C16H11D5F3NO . HCl. Formula Weight: 336.8. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, DMSO: slightly soluble. SMILES: FC(F)(F)C(C=C1)=CC=C1OC(C2=CC=CC=C2)([2H])C([2H])([2H])C([2H])([2H])N.Cl. InChi Code: InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12,/h1-9,15H,10-11,20H2,1H/i10D2,11D2,15D,. InChi Key: GMTWWEPBGGXBTO-KDPCSTGBSA-N.