Norfloxacin-d5

Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin (Cay-25975) by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 µg/ml for S. aureus and P. aeruginosa, respectively). It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 µg/ml, respectively). Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day. Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.Formal Name: 1-(ethyl-1,1,2,2,2-d5)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. CAS Number: 1015856-57-1. Molecular Formula: C16H13D5FN3O3. Formula Weight: 324.4. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly, DMSO: slightly, heated. SMILES: O=C(O)C1=CN(C([2H])([2H])C([2H])([2H])[2H])C2=CC(N3CCNCC3)=C(F)C=C2C1=O. InChi Code: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)/i1D3,2D2. InChi Key: OGJPXUAPXNRGGI-ZBJDZAJPSA-N.