Norcantharidin

Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Cay-14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively). It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a concentration of 5 µg/ml. Norcantharidin (500-5,000 µg/ml) reduces angiogenesis in a chick chorioallantoic membrane assay. It inhibits growth in a panel of nine human cancer cell lines, including breast, lung, skin, and glioblastoma cancer cells, with GI50 values ranging from 30 to 64 µM. Norcantharidin (28 mg/kg, i.p.) reduces tumor growth in a GBC-SD mouse xenograft model.Formal Name: (3aR,4S,7R,7aS)-rel-hexahydro-4,7-epoxyisobenzofuran-1,3-dione. CAS Number: 29745-04-8. Synonyms: Demethylcantharidin, NCTD, NSC 59023. Molecular Formula: C8H8O4. Formula Weight: 168.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMSO: 30mg/mL, Ethanol: 1mg/mL. lambdamax: 225 nm. SMILES: O=C1OC([C@@]2([H])[C@@H]3CC[C@@H](O3)[C@]21[H])=O. InChi Code: InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4+,5-,6+. InChi Key: JAABVEXCGCXWRR-FBXFSONDSA-N.