NLRP3-IN-2

Description: NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on metabolism. Target: NOD-like Receptor (NLR), NOD. Smiles: COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O. References: Baldwin, A., Brough, D., & Freeman, S. (2015). Inhibiting the Inflammasome: A Chemical Perspective. Journal Of Medicinal Chemistry, 59(5), 1691-1710. doi: 10.1021/acs.jmedchem.5b01091