Nizatidine

Histamine H2 receptors mediate gastric acid secretion by coupling to Galphas proteins and increasing cAMP formation. Nizatidine is a histamine H2 receptor antagonist that decreases gastric acid secretion (ED50 = 0.9 µM in isolated gastric mucosa of bullfrog and ED50s = 1.383 and 0.08 µmol/kg in rats and dogs, respectively). Its gastroprotective activity has been exploited in clinical studies of various gastric acid disorders.Formal Name: N'-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine. CAS Number: 76963-41-2. Synonyms: LY139037. Molecular Formula: C12H21N5O2S2. Formula Weight: 331.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 241, 326 nm. SMILES: CN/C(NCCSCC1=CSC(CN(C)C)=N1)=C\[N+]([O-])=O. InChi Code: InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+. InChi Key: SGXXNSQHWDMGGP-IZZDOVSWSA-N.