Nimustine (hydrochloride)

Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity. It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 µg/ml. Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.Formal Name: N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-urea, monohydrochloride. CAS Number: 55661-38-6. Synonyms: ACNU, NSC-D 245382. Molecular Formula: C9H13ClN6O2 . HCl. Formula Weight: 309.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 249 nm. SMILES: O=NN(CCCl)C(NCC1=CN=C(C)N=C1N)=O.Cl. InChi Code: InChI=1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10,/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14),1H. InChi Key: KPMKNHGAPDCYLP-UHFFFAOYSA-N.