Nimodipine-d7

Nimodipine-d7 is intended for use as an internal standard for the quantification of nimodipine (Cay-14573) by GC- or LC-MS. Nimodipine is an inhibitor of L-type voltage-gated calcium (Cav) channels. It is selective for Cav1.2 over Cav1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM. Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips. It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).Formal Name: 3-(2-methoxyethyl) 5-(propan-2-yl-d7) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. CAS Number: 1246815-36-0. Molecular Formula: C21H19D7N2O7. Formula Weight: 425.5. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: CC1=C(C(OCCOC)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=C(C)N1. InChi Code: InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3/i1D3,2D3,12D. InChi Key: UIAGMCDKSXEBJQ-QLWPOVNFSA-N.