Nimbolide

Description: Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-kappaB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-kappaB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L). Target: Apoptosis, CDK, NF-kappaB. Smiles: C[C@]12[C@]3([C@]([C@@]4([C@](C)([C@@H]1CC(OC)=O)C=5[C@](O4)(C[C@H](C5C)C=6C=COC6)[H])[H])(OC(=O)[C@]3(C)C=CC2=O)[H])[H]. References: Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug,28(5):1026-35.