(±)-Nicotine

(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for alpha3beta4 and alpha4beta2 subtypes, respectively) and possesses addictive and teratogenic properties. (-)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (-)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.Formal Name: 3-(1-methyl-2-pyrrolidinyl)-pyridine. CAS Number: 22083-74-5. Synonyms: DL-Nicotine. Molecular Formula: C10H14N2. Formula Weight: 162.2. Purity: >98%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 262 nm. SMILES: CN1CCCC1C2=CC=CN=C2. InChi Code: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3. InChi Key: SNICXCGAKADSCV-UHFFFAOYSA-N.