Nicotinamide riboside

Nicotinamide riboside is a riboside form of nicotinamide (Cay-11127) that is found in trace amounts in yeast-containing and milk-derived products. It is a precursor of NAD+ (Cay-16077) and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 µM. It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and 3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer's disease.Formal Name: 3-(aminocarbonyl)-1-beta-D-ribofuranosyl-pyridinium. CAS Number: 1341-23-7. Molecular Formula: C11H15N2O5. Formula Weight: 255.3. Purity: >95% Contains ~80% cyclodextrin as stabilizer. Formulation: (Request formulation change), A low-melting semi-solid. Solubility: Water: Soluble. SMILES: NC(C1=C[N+]([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=CC=C1)=O. InChi Code: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1. InChi Key: JLEBZPBDRKPWTD-TURQNECASA-O.