NFAT Activation Inhibitor III

NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Cay-10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.Formal Name: 9,10-dihydro-9,10[1',2']-benzenoanthracene-1,4-dione. CAS Number: 3519-82-2. Synonyms: INCA-6, NSC 25996, Nuclear Factor of Activated T cells Inhibitor III. Molecular Formula: C20H12O2. Formula Weight: 284.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 20 mg/mL, DMSO: 2 mg/mL. lambdamax: 210, 252 nm. SMILES: O=C(C1=C2C3C4=CC=CC=C4C1C5=CC=CC=C53)C=CC2=O. InChi Code: InChI=1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H. InChi Key: GCHPUOHXXCNSQL-UHFFFAOYSA-N.