Nemadipine A

Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel alpha1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester. CAS Number: 54280-71-6. Molecular Formula: C19H18F5NO4. Formula Weight: 419.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 15 mg/ml, Methanol: 100 mg/ml. lambdamax: 231, 365 nm. SMILES: CC1=C(C(OCC)=O)C(C2=C(F)C(F)=C(F)C(F)=C2F)C(C(OCC)=O)=C(C)N1. InChi Code: InChI=1S/C19H18F5NO4/c1-5-28-18(26)9-7(3)25-8(4)10(19(27)29-6-2)11(9)12-13(20)15(22)17(24)16(23)14(12)21/h11,25H,5-6H2,1-4H3. InChi Key: QABNLWXKUCMDBP-UHFFFAOYSA-N.