Nedometinib

Nedometinib is a MEK1 inhibitor (IC50 = 135 nM). It is selective for MEK1 over a panel of 44 receptors, ion channels, and enzymes at 10 µM, as well as a panel of an additional 150 kinases. Nedometinib (0.1-10 µM) decreases phosphorylation of ERK in malignant peripheral nerve sheath tumor cells. Topical application of nedometinib (0.1-2.3%) reduces the total number of tumors in a mouse model of cutaneous squamous cell carcinoma induced by UV radiation.Formal Name: 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide. CAS Number: 2252314-46-6. Synonyms: NFX-179. Molecular Formula: C17H16FIN4O3. Formula Weight: 470.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C(C(C1=CC=CN=C1N2C)=C2NC(C=CC(I)=C3)=C3F)NOCCO. InChi Code: InChI=1S/C17H16FIN4O3/c1-23-15-11(3-2-6-20-15)14(17(25)22-26-8-7-24)16(23)21-13-5-4-10(19)9-12(13)18/h2-6,9,21,24H,7-8H2,1H3,(H,22,25). InChi Key: SENAOZROGSYRTD-UHFFFAOYSA-N.