Necrosulfonamide

Necrosulfonamide is a small molecule that inhibits necroptosis by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIPK3). Necrosulfonamide has been shown to prevent the MLKL-RIPK1-RIPK3 necrosome complex from interacting with downstream necrosis effectors.Formal Name: (2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide. CAS Number: 1360614-48-7. Molecular Formula: C18H15N5O6S2. Formula Weight: 461.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMF:PBS (pH 7.2) (1:50): 0.5 mg/mL, DMSO: 20 mg/mL. lambdamax: 277, 366 nm. SMILES: O=S(C1=CC=C(NC(/C=C/C2=CC=C([N+]([O-])=O)S2)=O)C=C1)(NC3=C(OC)N=CC=N3)=O. InChi Code: InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+. InChi Key: FNPPHVLYVGMZMZ-XBXARRHUSA-N.