Necrostatin-1

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-alpha (TNF-alpha) induced necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-alpha-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM. It has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.Formal Name: 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. CAS Number: 4311-88-0. Synonyms: Nec-1. Molecular Formula: C13H13N3OS. Formula Weight: 259.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml, DMSO: 14 mg/ml, Ethanol: 3 mg/ml. lambdamax: 220, 266 nm. SMILES: O=C(C(N1)CC2=CNC3=CC=CC=C32)N(C)C1=S. InChi Code: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18). InChi Key: TXUWMXQFNYDOEZ-UHFFFAOYSA-N.