Nebularine

Nebularine is a purine ribonucleoside and an adenosine analog that has been found in L. nebularis and has diverse biological activities. It reduces herpes simplex virus 1 (HSV-1) viral plaque formation in Vero cells (IC50 = 0.6 µM) and is active against M. phlei, M. avium, M. tuberculosis, and B. abortus. Nebularine (10 and 100 µM) is cytotoxic to COS-7 cells and induces pyknosis in mouse sarcoma 180 cells and mouse embryonic skin explants in a concentration-dependent manner. It inhibits root growth of wheat seedlings when used at concentrations ranging from 0.1 to 2 mM. Nebularine also inhibits adenosine deaminase (Ki = 16 µM).Formal Name: 9-beta-D-ribofuranosyl-9H-purine. CAS Number: 550-33-4. Synonyms: Desaminoadenosine, NSC 65423, Purine riboside, Purinosine, Ribosylpurine. Molecular Formula: C10H12N4O4. Formula Weight: 252.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 244, 264 nm. SMILES: O[C@@H]1[C@H](O)[C@@H](CO)O[C@@]1([H])N2C=NC3=CN=CN=C32. InChi Code: InChI=1S/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2/t6-,7-,8-,10-/m1/s1. InChi Key: MRWXACSTFXYYMV-FDDDBJFASA-N. Origin: Synthetic.