NCT-02

NCT-02 is a degrader of cyclin K. It reduces the levels of cyclin K in patient-derived colorectal cancer (CRC) cells in a concentration-dependent manner. NCT-02 inhibits cancer cell proliferation in CRC tissue samples isolated from the colon (IC50s = 0.9-20.6 µM), as well as from hepatic, lung, and rectal metastases (IC50s = 0.5-11.8, 1, and 1.4-38.4 µM, respectively). It decreases the levels of Ataxia-telangiectasia mutated kinase (ATM) and RAD51 in patient-derived CRC tissues when used at concentrations 0.7 and 0.5 µM, respectively. NCT-02 (3 µM) reduces the number of spheroids formed and induces poly(ADP-ribose) polymerase (PARP) cleavage in patient-derived CRC spheroid cultures.Formal Name: 6,7-dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide. CAS Number: 790245-61-3. Molecular Formula: C17H16N2O2S. Formula Weight: 312.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O=C(NC1=NC=C(C)S1)CC2=COC3=C2C=C(CCC4)C4=C3. InChi Code: InChI=1S/C17H16N2O2S/c1-10-8-18-17(22-10)19-16(20)7-13-9-21-15-6-12-4-2-3-11(12)5-14(13)15/h5-6,8-9H,2-4,7H2,1H3,(H,18,19,20). InChi Key: IELCYEUTXLYDOV-UHFFFAOYSA-N.