NAMPT inhibitor-linker 1

Description: NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively. Target: Others, Drug-Linker Conjugates for ADC. Smiles: Fc1cc(NC(=O)[C@H]2C[C@@H]2c2cccnc2)ccc1CNC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CCOCCN1C(=O)C=CC1=O. References: Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28,9(8):838-842.