Nampt-IN-1

Description: Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM. Target: NAMPT, c-Fms, CSF-1R. Smiles: CC(C)(O)CS(=O)(=O)NC1=CC2=C(CN(CC2)C(=O)COC2=CC=CN=C2)C=C1. References: Zhao G, et al. Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration. Mol Cancer Ther. 2017 Dec,16(12):2677-2688.