Nafcillin (sodium salt hydrate)

Nafcillin is a semisynthetic and penicillinase-resistant penicillin antibiotic. It is active against 20 clinical isolates of S. aureus with minimum bactericidal concentration (MBC) values ranging from 0.078 to 0.312 µg/ml. Nafcillin (100-800 mg/kg) reduces the number of kidney colony forming units (CFUs) in a mouse model of S. aureus infection. It also reduces the number of right atrial CFUs in a rabbit model of S. aureus-induced endocarditis. Formulations containing nafcillin have been used in the treatment of various bacterial infections.Formal Name: 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt, monohydrate. CAS Number: 7177-50-6. Molecular Formula: C21H21N2O5S . Na [H2O]. Formula Weight: 454.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 226, 228, 279, 333 nm. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O)C3=C(C=CC=C4)C4=CC=C3OCC.[Na+].O. InChi Code: InChI=1S/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23,,/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27),,1H2/q,+1,/p-1/t15-,16+,19-,,/m1../s1. InChi Key: OCXSDHJRMYFTMA-KMFBOIRUSA-M.