N6-Succinyl Adenosine

Succinyladenosine (S-Ado) is a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis.  S-Ado has been previously reported as normally undetectable in cerebrospinal fluid (CSF) of children not suffering from this defect. Synonyms: N-(9-beta-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartic Acid, 6-(1,2-Dicarboxyethylamino), -9-beta-D-ribofuranosylpurine, (S)-N-(1,2-Dicarboxyethyl)adenosine, Succinoadenosine, CAS No: 4542-23-8, Molecular Formula: C14H17N5O8, Molecular Weight: 383.31, Appearance: Supplied as a white solid. Purity: ?95%, Melting Point: >180ºC (dec), Solubility: DMSO (slightly), Methanol (slightly), Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis, TLC Conditions: C18, Acetonitrile: Water = 8:2, Visualized with UV and AMCS, SIngle spot, Rf=0.70, Specific Rotation: -29ºC (c=0.3, Methanol), Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt.. For maximum recovery of product, centrifuge the original vial prior to removing the cap.